KU-55933
| Overview | |
| Catalog # | bs-82299c-5mg |
| Product Name | KU-55933 |
| Specifications | |
| Storage Buffer | Tan solid |
| Storage Condition | -20°C |
| Target | |
| Product Information | Potent and selective ATM kinase inhibitor IC50s= 13, 2500, 9300, 16600, >100000 and >100000 nM for ATM, DNA-PK, mTOR, PI 3-kinase, PI 4-K and ATR respectively.1 Decreases viability of MCF-7, A549 and HCT116 cells and decreases p21CIP1 levels in vitro.2 Disruption of ATM signaling in primary A-T fibroblasts leads to dysregulation of ribonucleotide reductase and increase resistance to inhibitors of mitochondrial respiration and translation.3 Sensitizes radio-resistant cancer cells.4 Provides neuroprotection against H2O2-induced cell damage.5 |
| Description | CAS Number: 587871-26-9 Chemical Name: 2-(4-Morpholinyl)-6-(1-thiamthrenyl)-4H-pyran-4-one Molecular weight: 395.50 Formula: C21H17NO3S2 Solubility: DMSO (40 mg/ml) Ethanol (20 mg/ml) Physical Properties: Tan solid Purity: 98% by TLC, NMR (Conforms) |
Frequently asked questions
Which applications is KU-55933 (bs-82299C) validated for, and at what dilution?
bs-82299C is validated for Life Science( N/A).
How should bs-82299C be stored?
-20°C Storage buffer: Tan solid