Halofuginone HBr
| Overview | |
| Catalog # | bs-82477c-10mg |
| Product Name | Halofuginone HBr |
| Specifications | |
| Storage Buffer | White solid |
| Storage Condition | -20°C |
| Target | |
| Product Information | Potent and selective prolyl-tRNA synthetase (PRS) inhibitor (Ki=18.3 nM) derived from febrifugine.1 Also attenuates TGF-β signaling, including reversibly reducing Smad3 protein levels and inhibiting fibroblast differentiation.2 Blocks fibrosis, angiogenesis, and tumor progression.2,3 Inhibition of PRS results in amino acid starvation which activates the integrated stress response (ISR) and mTOR signaling4 and thus preventing differentiation of TH17 cells, suppressing the autoimmune response5. Reduces TMPRSS2 protein levels via enhanced ubiquitination and proteasomal degradation, limiting SARS-CoV-2 cellular entry.6 |
| Description | CAS Number: 64924-67-0 Chemical Name: (2R,3S)-7-Bromo-6-chloro-3-[3-(3-hydroxy-2-piperidinyl)-2-oxopropyl]-4-3H-quinazolinone hydrobromide Molecular weight: 495.6 Formula: C16H17BrClN3O3 • HBr Solubility: DMSO (30 mg/ml) Physical Properties: White solid Purity: >98% by TLC NMR (Conforms) |
Frequently asked questions
Which applications is Halofuginone HBr (bs-82477C) validated for, and at what dilution?
bs-82477C is validated for Life Science( N/A).
How should bs-82477C be stored?
-20°C Storage buffer: White solid