Migalastat

Overview
Catalog #	bs-82542c-1mg
Product Name	Migalastat
Specifications
Storage Buffer	White solid
Storage Condition	-20°C
Target
Product Information	Migalastat is a potent, selective, and orally available inhibitor of α-galactosidase A (IC50= 40 nM).1 It binds to mutant misfolded α-GalA shifting the folding behavior toward functional active conformation (pharmacological chaperone activity) followed by trafficking to the lysosomes.2 Migalastat is active broadly across species from Drosophila3 to human4. Clinically useful agent for Fabry disease.5
Description	CAS Number: 75172-81-5 Chemical Name: (2R,3S,4R,5S)-2-(Hydroxymethyl)-3,4,5-piperidinetriol HCl Molecular weight: 199.63 Formula: C6H13NO4 • HCl Solubility: DMSO (50 mg/ml) Physical Properties: White solid Purity: >98% by TLC, NMR (Conforms)