ANA-12
| Overview | |
| Catalog # | bs-82591c-5mg |
| Product Name | ANA-12 |
| Specifications | |
| Storage Buffer | White solid |
| Storage Condition | -20°C |
| Target | |
| Product Information | TrkB receptor antagonist. Binds to two distinct receptor sites preventing activation by BDNF non-competitively, IC50 = 45.6 nM and 41.1 μM for the high and low affinity sites respectively. Systemic administration to adult mice decreased TrkB activity in the brain without affecting neuronal survival or altering TrkA and TrkC functions. Displays antidepressant and anxiolytic properties in mouse models after systemic administration1. Shows antidepressant effects on LPS-induced depression-like behavior in mice2. Has been used to elucidate the role of BDNF in improvement of cognitive decline during calorie restriction3 and in the discovery of new neurotrophic agents4. |
| Description | CAS Number: 219766-25-3 Chemical Name: N-[2-[[(Hexahydro-2-oxo-1H-azepin-3-yl)amino]carbonyl]phenyl]benzo[b]thiophene-2-carboxamide Molecular weight: 407.49 Formula: C22H21N3O3S Solubility: DMSO (20 mg/ml) Physical Properties: White solid Purity: 98% by TLC, NMR (Conforms) |
Frequently asked questions
Which applications is ANA-12 (bs-82591C) validated for, and at what dilution?
bs-82591C is validated for Life Science( N/A).
How should bs-82591C be stored?
-20°C Storage buffer: White solid