Brequinar sodium

Overview
Catalog #	bs-82740c-10mg
Product Name	Brequinar sodium
Specifications
Storage Buffer	White to off-white solid
Storage Condition	-20°C
Target
Product Information	Brequinar sodium is an inhibitor of dihydroorotate dehydrogenase (DHODH)1,2 with IC50’s between 0.2 and 5.8 µM in various cell lines3 and 20 nM in isolated enzyme4. It reduced leukemic cell burden, decreased levels of leukemia-initiating cells, and improved survival in human and mouse models of acute myeloid leukemia.4 Brequinar displayed broad antiviral activity against flaviviruses, positive-strand RNA alphaviruses, negative-strand RNA rhabdoviruses, Influenza A and B viruses, and HIV.5,6,7
Description	CAS Number: 96201-88-6 Chemical Name: 6-Fluoro-2-[4-(2-fluorophenyl)phenyl]-3-methylquinoline-4-carboxylic acid sodium salt Molecular weight: 397.35 Formula: C23H14F2NO2·Na Solubility: DMSO (>25 mg/ml) Water (15 mg/ml) Physical Properties: White to off-white solid Purity: 99% by HPLC NMR Conforms