RS-1
| Overview | |
| Catalog # | bs-82789c-10mg |
| Product Name | RS-1 |
| Specifications | |
| Storage Buffer | White solid |
| Storage Condition | RT |
| Target | |
| Product Information | RAD51 is a strand exchange protein that is critical for the central steps in homologous recombination (HR) of DNA during double strand break repair. Because HR usually occurs without mutations, it is critically important for maintaining genomic stability. RS-1 is a small molecule that enhances the HR activity of RAD51 by promoting the formation of active presynaptic filaments during repair.1 At low micromolar levels, it was able to increase cellular resistance of neonatal human dermal fibroblasts to the chemotherapeutic agent cisplatin. HR stimulation in various cell types could lead to temporary protection from DNA damaging agents. RS-1 has been used to exploit the RAD51 overexpression in cancerous cells by inducing lethality via genotoxic RAD51 protein complexes.2 RS-1 has also been found to a potent enhancer of CRISPR- and TALEN- based gene editing.3,4 |
| Description | CAS Number: 312756-74-4 Chemical Name: 4-Bromo-N-(4-bromophenyl)-3-[[(phenylmethyl)amino]sulfonyl]benzamide Molecular weight: 524.23 Formula: C20H16BrN2O3S Solubility: DMSO (>30 mg/ml) Physical Properties: White solid Purity: 99% by HPLC, NMR (Conforms) |
Frequently asked questions
Which applications is RS-1 (bs-82789C) validated for, and at what dilution?
bs-82789C is validated for Life Science( N/A).
How should bs-82789C be stored?
RT Storage buffer: White solid