GSK2636771

Overview
Catalog #	bs-82814c-5mg
Product Name	GSK2636771
Specifications
Storage Buffer	Pale yellow solid
Storage Condition	-20°C
Target
Product Information	GSK2636771 is a potent, selective (>1000-fold over α, 10-fold over δ, and >2000-fold over γ), and orally bioavailable inhibitor of PI3Kß (IC50 = 5.2 nM).1 Active in vitro against multiple types of PTEN-deficient cancer cells. GSK2636771 potently blocked migration and invasion of DU145 prostate cancer cells.2 GSK2636771 has also been identified as a GPR39 agonist.3
Description	CAS Number: 1372540-25-4 Chemical Name: 2-Methyl-1-(2-methyl-3-(trifluoromethyl)benzyl)-6-morpholino-1H-benzo[d]imidazole-4-carboxylic acid Molecular weight: 433.43 Formula: C22H22F3N3O3 Solubility: DMSO (20 mg/ml) Physical Properties: Pale yellow solid Purity: >98% by HPLC NMR (Conforms)