GSK2830371

Overview
Catalog #	bs-82816c-5mg
Product Name	GSK2830371
Specifications
Storage Buffer	Tan solid
Storage Condition	-20°C
Target
Product Information	Potent allosteric inhibitor of WIP1 phosphatase (IC50 = 6 nM), a negative regulator of the DNA damage response.1 It displayed no inhibition of 21 other phosphatases. Active in xenograft model DoHH2 B-cell lymphoma. GSK2830371 in combination with MDM2 inhibitors has been shown to be efficacious in the treatment of various cancers including liver adenocarcinoma2, acute myeloid leukemia3, and breast4. It enhances phosphorylation of the tumor suppressor p53 leading to activation.5,6
Description	CAS Number: 1404456-53-6 Chemical Name: 5-[[(5-Chloro-2-methylpyridin-3-yl)amino]methyl]-N-[(2S)-3-cyclopentyl-1-(cyclopropylamino)-1-oxopropan-2-yl]thiophene-2-carboxamide Molecular weight: 461.02 Formula: C23H29ClN4O2S Solubility: DMSO (>25 mg/ml) Physical Properties: Tan solid Purity: 97% by HPLC NMR (Conforms)