Dynarrestin
| Overview | |
| Catalog # | bs-82819c-5mg |
| Product Name | Dynarrestin |
| Specifications | |
| Storage Buffer | Pale pink/purple solid |
| Storage Condition | -20°C |
| Target | |
| Product Information | Dynarrestin is a reversible inhibitor of cytoplasmic dyneins 1 and 2.1 It inhibits dynein 1-dependent microtubule binding and motility without affecting ATP hydrolysis as well as dynein 2-dependent intraflagellar transport of the cargo IFT88 and flux of Smoothened within cilia without interfering with ciliogenesis. Dynarrestin suppresses hedgehog-dependent proliferation of neuronal precursors and tumor cells. It binds protein tyrosine phosphatase interacting protein 51 (PTPIP51) leading to increased MAPK activation and complete blockade of Akt signaling in Her2 positive breast cancer cells (SKBR3).2 |
| Description | CAS Number: 2222768-84-3 Chemical Name: Ethyl 4-(4-(diethylamino)phenyl)-2-((2,4-difluorophenyl)amino)thiozole-5-carboxylate Molecular weight: 431.5 Formula: C22H23F2N3O2S Solubility: DMSO (>40 mg/ml) Physical Properties: Pale pink/purple solid Purity: >98% by HPLC NMR (Conforms) |
Frequently asked questions
Which applications is Dynarrestin (bs-82819C) validated for, and at what dilution?
bs-82819C is validated for Life Science( N/A).
How should bs-82819C be stored?
-20°C Storage buffer: Pale pink/purple solid