Quinacrine hydrochloride

Overview
Catalog #	bs-82833c-20-mg
Product Name	Quinacrine hydrochloride
Specifications
Storage Buffer	Yellow solid
Storage Condition	-20°C
Target
Product Information	Quinacrine is an antiprotozoan drug used for malaria and giardiasis and has recently been investigated in treating lupus, as an anticancer agent, inflammation, and as a female sterilization agent.1 It has been found to have synergistic effects with vorinostat in the treatment of T-cell acute lymphoblastic leukemia via mitophagy blockage and an increase in ROS.2 Quinacrine displayed antitumor effects an intestinal cancer mouse model and HCT116 p53-/- xenografts via reduction in Chk1/2 expression and cell death induction in the G2-M phase.3 It promotes autophagic cell death in ovarian cancer cells via downregulation of p62/SQSTM1.4 Quinacrine is also an inhibitor of phospholipase A2.5
Description	CAS Number: 69-05-6 Chemical Name: 6-Chloro-9-(4-diethylamino-1-methylbutyl)amino-2-methoxyacridine dihydrochloride Molecular weight: 472.88 Formula: C23H30ClN3O·2HCl Solubility: Water (>25 mg/ml) DMSO (>10 10 mg/ml) Physical Properties: Yellow solid Purity: 98% by HPLC, NMR (Confirms)