TH588

Overview
Catalog #	bs-82939c-5mg
Product Name	TH588
Specifications
Storage Buffer	White solid
Storage Condition	-20°C
Target
Product Information	TH588 is a first-in-class nudix hydrolase family inhibitor.1 MTH1/NUDT1 is a family member that “sanitizes” oxidized deoxynucleotide triphosphates (dNTP) preventing their incorporation into DNA and thus avoiding DNA damage and cell death. TH588 inhibits MTH1/NUDT1 (IC50 = 5 nM) leading to cell death in several cancer cell lines while not affecting normal cells. Active in vitro and in vivo. Recent evidence has raised doubts about the cancer-killing ability of MTH1 inhibition.2,3
Description	CAS Number: 1609960-31-7 (free base) Chemical Name: N4-Cyclopropyl-6-(2,3-dichlorophenyl)pyrimidine-2,4-diamine hydrochloride Molecular weight: 331.63 Formula: C13H12Cl2N4·HCl Solubility: DMSO (5 mg/ml) Physical Properties: White solid Purity: 98% by TLC, NMR (Conforms)