SM-88

Overview
Catalog #	bs-82965c-10mg
Product Name	SM-88
Specifications
Storage Buffer	Off-white solid
Storage Condition	RT
Target
Product Information	A “dysfunctional” tyrosine mimetic. It is taken up by cancer cells and disrupts tyrosine-mediated metabolic pathways including synthesis of the important protein mucin-1 leading to oxidative stress.1 In clinical trials with melanin, phenytoin, and sirolimus (SMK therapy) for use in advanced metastatic cancer2, in combination with methoxsalen, phenytoin, and sirolimus (MPS therapy) for prostate cancer3, and as monotherapy for metastatic pancreatic cancer4. It is also an inhibitor of tyrosine hydroxylase resulting in a reduction of catecholamines and their metabolites.5
Description	CAS Number: 30625-05-9 Chemical Name: 2-Amino-3-(4-hydroxyphenyl)-2-methylpropionic acid hydrochloride Molecular weight: 231.68 Formula: C10H13NO3·HCl Solubility: DMSO (>50 mg/ml) Ethanol (>35 mg/ml) Physical Properties: Off-white solid Purity: >98% by TLC (NMR Conforms)