AZ20

Overview
Catalog #	bs-82981c-5mg
Product Name	AZ20
Specifications
Storage Buffer	Off-white solid
Storage Condition	-20°C
Target
Product Information	AZ20 is a potent and highly selective inhibitor of Ataxia telangiectasia mutated and RAD3-related (ATR) kinase (IC50 = 5 nM in vitro; IC50 = 50 nM in HT29 colorectal adenocarcinoma cells).1 Combination therapy with AZ20 and gemcitabine resulted in synergistic inhibition of tumor cell growth and cell death initiation in pancreatic cancer cell lines.2
Description	CAS Number: 1233339-22-4 Chemical Name: 4-{4-[(3R)-3-Methyl-4-morpholinyl]-6-[1-(methylsulfonyl)cyclopropyl]-2-pyrimidinyl}-1H-indole Molecular weight: 412.51 Formula: C21H24N4O3S Solubility: DMSO (20 mg/ml) Physical Properties: Off-white solid Purity: 98% by HPLC NMR (Conforms)