PF-670462 dihydrochloride
| Overview | |
| Catalog # | bs-82991c-5mg |
| Product Name | PF-670462 dihydrochloride |
| Specifications | |
| Storage Buffer | Off-white solid |
| Storage Condition | -20°C |
| Target | |
| Product Information | Potent inhibitor of casein kinase 1ε/δ (CK1ε, IC50 = 7.7 nM; CK1δ, IC50 = 14 nM).1 It is a circadian clock modifier that caused robust phase delays in rats1 and Cynomolgus monkeys2. PF-670462 caused nuclear retention of the clock protein PER resulting in period lengthening in a phase-specific manner that was dependent on CK1δ inhibition and not CK1ε.3 It improved cognitive performance and reduced amyloid load in various mouse models of Alzheimer’s disease.4-6 PF-670462 slowed the progression of and increased survival of chronic lymphocytic leukemia in mice alone and in combination with Ibrutinib.7 |
| Description | CAS Number: 950912-80-8 Chemical Name: 4-[3-Cyclohexyl-5-(4-fluorophenyl)imidazol-4-yl]pyrimidin-2-amine 2HCl Molecular weight: 337.4 Formula: C19H22Cl2FN5 Solubility: DMSO (25 mg/ml) Physical Properties: Off-white solid Purity: >98% by HPLC, NMR (Conforms) |
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