CB-103

Overview
Catalog #	bs-83004c-20-mg
Product Name	CB-103
Specifications
Storage Buffer	Off-white to pale orange solid
Storage Condition	RT
Target
Product Information	Orally active inhibitor of the Notch signaling activation complex (IC50’s from 0.9 to 3.9 µM in various cell-based assays), the most downstream level of the Notch signaling pathway. It inhibited the growth of Notch-addicted human T cell acute lymphoblastic leukemia cells as well as other cell lines. CB-103 also inhibited the growth of human breast cancer and leukemia xenografts without the intestinal toxicity associated with γ-secretase Notch inhibitors.
Description	CAS Number: 218457-67-1 Chemical Name: 5-Amino-2-(4-tert-butylphenoxy)pyridine Molecular weight: 242.32 Formula: C15H18N2O Solubility: DMSO (>30 mg/ml) Physical Properties: Off-white to pale orange solid Purity: 98% by HPLC, NMR (Conforms)