GSK583

Overview
Catalog #	bs-83008c-10mg
Product Name	GSK583
Specifications
Storage Buffer	Pale yellow solid
Storage Condition	-20°C
Target
Product Information	GSK583 is a highly selective and potent inhibitor of RIP2 kinase, IC50 = 5 nM human and IC50 = 2 nM rat.1 It also potently Inhibits isolated RPI3 kinase (IC50 = 5 nM) but is inactive against RIP3 in cellular assays due to a very low KM,ATP. GSK583 blocks NOD2 signaling by interfering with XIAP-RIP2 binding resulting in decreased cytokine and chemokine production.1,2
Description	CAS Number: 1346547-00-9 Chemical Name: 6-tert-Butylsulfonyl-N-(5-fluoro-1H-indazol-3-yl)quinoline-4-amine Molecular weight: 398.45 Formula: C20H19FN4O2S Solubility: DMSO (>25 mg/ml) Physical Properties: Pale yellow solid Purity: 98% by HPLC NMR (Conforms)