Adavosertib
| Overview | |
| Catalog # | bs-83036c-5mg |
| Product Name | Adavosertib |
| Specifications | |
| Storage Buffer | Yellow solid |
| Storage Condition | -20°C |
| Target | |
| Product Information | Inhibits Wee1 tyrosine kinase (IC50 = 5.2 nM) thus preventing phosphorylation of CDC2 and abrogating the G2 DNA damage checkpoint, sensitizing a variety of tumor cells to DNA damaging agents.1 Adavosertib also blocks Wee1 phosphorylation of E3 ubiquitin ligase SKP2 in human cells, ultimately preventing degradation of CDKs and further allowing cell cycle progression.2 Stimulates anti-tumor immunity and enhances sensitivity to immune checkpoint blockade by activating ERV and the dsRNA pathway.3 Potentiates sensitivity of tumors to PARP inhibitors.4 |
| Description | CAS Number: 955365-80-7 Chemical Name: 1,2-Dihydro-1-[6-(1-hydroxy-1-methylethyl)-2-pyridinyl]-6-[[4-(4-methyl-1-piperazinyl)-phenyl]amino]-2-(2-propen-1-yl)-3H-pyrazolo[3,4-d]pyrimidin-3-one Molecular weight: 500.61 Formula: C27H32N8O2 Solubility: DMSO (70 mg/ml) Physical Properties: Yellow solid Purity: >98% by TLC NMR (Conforms) |
Frequently asked questions
Which applications is Adavosertib (bs-83036C) validated for, and at what dilution?
bs-83036C is validated for Life Science( N/A).
How should bs-83036C be stored?
-20°C Storage buffer: Yellow solid