Sitravatinib
| Overview | |
| Catalog # | bs-83037c-5mg |
| Product Name | Sitravatinib |
| Specifications | |
| Storage Buffer | Off-white solid |
| Storage Condition | -20°C |
| Target | |
| Product Information | Sitravatinib is a broad spectrum receptor tyrosine kinase inhibitor. Its targets include Axl, c-Met, PDGFR, VEGFR, Ephrin receptor family, and FLT3 among others at nanomolar levels.1 Sitravatinib has been tested in mouse models of sarcoma and showed better efficacy than both imatinib and crizotinib. Because of its unique kinase inhibition profile (especially that of TAM receptors), it has been used to restore response to anti-PD-1 therapy (nivolumab) in NSCLC patients.2 Sitravatinib was able to significantly alter the immunosuppressive tumor microenvironment in three preclinical tumor models to enhance the effects of PD-1 blockade therapy.3 |
| Description | CAS Number: 1123837-84-2 Chemical Name: 1-N’-[3-Fluoro-4-[2-[5-[(2-methoxyethylamino)methyl]pyridin-2-yl]thieno[3,2-b]pyridin-7-yl]oxyphenyl]-1-N-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide Molecular weight: 629.68 Formula: C33H29F2N5O4S Solubility: DMSO (>25 mg/ml) Ethanol (>25 mg/ml) Physical Properties: Off-white solid Purity: 98% by HPLC NMR (Conforms) |
Frequently asked questions
Which applications is Sitravatinib (bs-83037C) validated for, and at what dilution?
bs-83037C is validated for Life Science( N/A).
How should bs-83037C be stored?
-20°C Storage buffer: Off-white solid