UNC0379

Overview
Catalog #	bs-83051c-5mg
Product Name	UNC0379
Specifications
Storage Buffer	Tan solid
Storage Condition	-20°C
Target
Product Information	UNC0379 is an inhibitor of the lysine methyltransferase SETD8 with selectivity over 15 other methyltransferases.1 IC50’s = 7.3 µM in a radioactive methyl transfer assay and 9.0 µM in an MCE assay. UNC0379 treatment of SY5Y and NGP neuroblastoma cell lines lead to activation of p53 and decreased tumor growth in an ex-vivo tumorigenicity assay.2
Description	CAS Number: 1620401-82-2 Chemical Name: 6,7-Dimethoxy-2-(pyrrolidin-1-yl)-N-(5-(pyrrolidin-1-yl)-pentyl)quinazolin-4-amine Molecular weight: 413.56 Formula: C23H35N5O2 Solubility: DMSO (>30 mg/ml) Physical Properties: Tan solid Purity: 98% by TLC NMR (Conforms)