ML401
| Overview | |
| Catalog # | bs-83109c-5mg |
| Product Name | ML401 |
| Specifications | |
| Storage Buffer | White solid |
| Storage Condition | -20°C |
| Target | |
| Product Information | ML401 is a potent antagonist of GPR183 (IC50 = 1.03 nM), also known as EBI2 or Epstein-Barr virus-induced gene 2. ML401 inhibited 7α,25-dihydroxycholesterol-induced RS11846 cell chemotaxis, IC50=6 nM.1 GPR183 is a key chemotactic receptor guiding B cell localization to appropriate microenvironments for activation and differentiation.2 It also regulates the homeostasis, localization and immunological function of splenic dendritic cells.3 Oxysterols have been shown to be endogenous ligands for GPR183 with 7α,25-dihydroxycholesterol being the most potent (Kd=450 pM).4 |
| Description | CAS Number: 1597489-14-9 Chemical Name: (E)-3-(4-Bromophenyl)-1-(4-(4-chlorobenzyl)piperazin-1-yl)prop-2-en-1-one Molecular weight: 419.75 Formula: C20H20BrClN2O Solubility: DMSO (45 mg/ml) Physical Properties: White solid Purity: >98% by TLC NMR (Conforms) |
Frequently asked questions
Which applications is ML401 (bs-83109C) validated for, and at what dilution?
bs-83109C is validated for Life Science( N/A).
How should bs-83109C be stored?
-20°C Storage buffer: White solid