Ketoconazole (base)
| Overview | |
| Catalog # | bs-83136c-100mg |
| Product Name | Ketoconazole (base) |
| Specifications | |
| Storage Buffer | Off-white solid |
| Storage Condition | RT |
| Target | |
| Product Information | Ketoconazole is a broad spectrum antifungal agent which acts via inhibition of a cytochrome P450, CYP51A1 which is a lanosterol 14-demethylase.1 Also inhibits CYP3A and CYP1A1.2 Inhibits adrenal steroidogenesis.3 Downregulates cholesterol synthesis in drug-tolerant human lung cancer cell lines.4 Blocks the biosynthesis of leukotrienes (LT) via inhibition of 5-lipoxygenase and dose dependently inhibits LT-mediated bronchoconstriction in guinea pigs.5 |
| Description | CAS Number: 65277-42-1 Chemical Name: Cytochrome P450 inhibitor Molecular Weight: 531.43 Formula: C26H28Cl2N4O4 Solubility: DMSO (25 mg/ml); Ethanol (20 mg/ml) Physical Properties: Off-white solid Purity: >98% by TLC |
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