GW-501516

Overview
Catalog #	bs-83217c-25mg
Product Name	GW-501516
Specifications
Storage Buffer	Off-white solid
Storage Condition	-20°C
Target
Product Information	Potent and selective PPARδ (NR1C2) agonist, EC50=1.2 nM and 1000-fold selective over other PPAR subtypes.1 Induces apolipoprotein A1-mediated cholesterol efflux in vitro.1 Improves hematopoietic stem cell maintenance.2 Prevents downregulation of AMPK caused by a high-fat diet in liver and increases fatty acid oxidation.3 Upregulates human Sirt1 via Sp1 activation.4 Along with exercise, GW-501516 synergistically increases running endurance.5
Description	CAS Number: 317318-70-0 Chemical Name: PPARδ agonist Molecular Weight: 453.50 Formula: C21H18F3NO3S2 Solubility: DMSO (40 mg/ml) Ethanol (20 mg/ml) Physical Properties: Off-white solid Purity: 98% by TLC NMr (Conforms)