NSC47924

Overview
Catalog #	bs-83219c-25mg
Product Name	NSC47924
Specifications
Storage Buffer	Yellow solid
Storage Condition	-20°C
Target
Product Information	A potent inhibitor of the Leucine-rich repeat protein phosphatase (PHLPP) an enzyme which is a negative regulator of Akt and PKC (IC50=4 M).1 Increases AKT signaling in cells and prevents apoptosis. Also inhibits the 67 kDa laminin receptor (LR) interaction with laminin (LM) and selectively blocks LR-293 cell adhesion to LM IC50=19.35 M) impairing cell migration and invasion.2 Affects 37/67 kDa LR cell surface localization and interaction with cellular prion protein.3
Description	CAS Number: 6638-24-0 Chemical Name: PHLP phosphatase inhibitor / Laminin inhibitor Molecular Weight: 279.33 Formula: C18H17NO2 Solubility: DMSO (30 mg/ml) Ethanol (10 mg/ml) Physical Properties: Yellow solid Purity: 98% by TLC NMR (Conforms)