Entacapone

Overview
Catalog #	bs-83225c-50mg
Product Name	Entacapone
Specifications
Storage Buffer	Yellow solid
Storage Condition	-20°C
Target
Product Information	Potent catechol O-methyltransferase (COMT) inhibitor (IC50 = 14.3, 20.1 and 73.3 nM for rat liver soluble COMT, total COMT and membrane-bound COMT respectively).1 Increases bioavailability of L-DOPA as adjunct therapy for Parkinson's disease.2 Inhibits α-synuclein aggregation in vitro and inhibits α-synuclein-induced cell death in PC-12 cells3. Antioxidant. Inhibits oxidative stress-induced cell death4.
Description	CAS Number: 130929-57-6 Chemical Name: COMT inhibitor - anti-Parkinsons Molecular Weight: 305.29 Formula: C14H15N3O5 Solubility: DMSO (30 mg/ml) Ethanol (3 mg/ml) Physical Properties: Yellow solid Purity: 98% by HPLC, NMR (Conforms)