Ionomycin

Overview
Catalog #	bs-83235c-5mg
Product Name	Ionomycin
Specifications
Storage Buffer	Yellow oil or waxy solid
Storage Condition	-20°C
Target
Product Information	Highly selective nonfluorescent calcium (Ca2+) ionophore.1 Induces a rapid rise in cytosolic Ca2+ in human neutrophils which is due to both release from cytosolic Ca2+ stores as well as Ca2+ influx.2 It activates (2 μM) and primes (20-200 nM) neutrophil NADPH oxidase2. Down regulates beta-catenin/Tcf signaling in a colon cancer cell line via suppressing the binding of Tcf to its specific DNA-binding site.3 In rat hepatoma cells, sub-lethal ionomycin activates the stress response by activating SAPK/JNK and HSF/HSE interaction leading to upregulation of HSP70 biosynthesis.4
Description	CAS Number: 56092-81-0 Chemical Name: Calcium ionophore Molecular Weight: 709.01 Formula: C41H72O9 Solubility: DMSO (10 mg/ml) Ethanol (10 mg/ml) Physical Properties: Yellow oil or waxy solid Purity: 98% by TLC, NMR (Conforms)