Gemcitabine HCl

Overview
Catalog #	bs-83256c-50mg
Product Name	Gemcitabine HCl
Specifications
Storage Buffer	White solid
Storage Condition	-20°C
Target
Product Information	Gemcitabine is a clinically useful anticancer agent.1 It exerts its cytotoxic effects via the metabolites gemcitabine diphosphate (dFdCDP) and gemcitabine triphosphate (dFdCTP). dFdCTP is an inhibitor of DNA polymerase and is also incorporated in DNA strands resulting in termination of chain elongation and apoptosis. dFdCDP is an inhibitor of ribonucleotide reductase which results in depletion of deoxyribonucleotides needed for DNA synthesis. Gemcitabine metabolites have also been reported to inhibit cytidine triphosphate synthetase (CTP synthetase)2 and deoxycytidylate deaminase (dCMP deaminase)3. Topoisomerase 1 has also been shown to be a target for gemcitabine.4
Description	CAS Number: 122111-03-9 Chemical Name: DNA polymerase inhibitor Molecular Weight: 299.66 Formula: C9H11F2N3O4·HCl Solubility: DMSO (20 mg/ml) Water (25 mg/ml) Physical Properties: White solid Purity: 98%