Gemcitabine HCl
| Overview | |
| Catalog # | bs-83256c-50mg |
| Product Name | Gemcitabine HCl |
| Specifications | |
| Storage Buffer | White solid |
| Storage Condition | -20°C |
| Target | |
| Product Information | Gemcitabine is a clinically useful anticancer agent.1 It exerts its cytotoxic effects via the metabolites gemcitabine diphosphate (dFdCDP) and gemcitabine triphosphate (dFdCTP). dFdCTP is an inhibitor of DNA polymerase and is also incorporated in DNA strands resulting in termination of chain elongation and apoptosis. dFdCDP is an inhibitor of ribonucleotide reductase which results in depletion of deoxyribonucleotides needed for DNA synthesis. Gemcitabine metabolites have also been reported to inhibit cytidine triphosphate synthetase (CTP synthetase)2 and deoxycytidylate deaminase (dCMP deaminase)3. Topoisomerase 1 has also been shown to be a target for gemcitabine.4 |
| Description | CAS Number: 122111-03-9 Chemical Name: DNA polymerase inhibitor Molecular Weight: 299.66 Formula: C9H11F2N3O4·HCl Solubility: DMSO (20 mg/ml) Water (25 mg/ml) Physical Properties: White solid Purity: 98% |
Frequently asked questions
Which applications is Gemcitabine HCl (bs-83256C) validated for, and at what dilution?
bs-83256C is validated for Life Science( N/A).
How should bs-83256C be stored?
-20°C Storage buffer: White solid