Vandetanib

Overview
Catalog #	bs-83268c-50mg
Product Name	Vandetanib
Specifications
Storage Buffer	White or off-white solid
Storage Condition	-20°C
Target
Product Information	A potent and selective inhibitor of VEGFR2, (KDR IC50 = 40 nM). Also inhibits fms-like tyrosine kinase 4 (VEGFR3, IC50 = 110 nM) and epidermal growth factor receptor (EGFR/HER1, IC50 = 500 nM) but shows selectivity against a panel of other tyrosine and serine-threonine kinases. Inhibits colony formation in seven cancer cell lines2. Displays anti-angiogenesis activity3.
Description	CAS Number: 443913-73-3 Chemical Name: VEGFRK inhibitor Molecular Weight: 475.35 Formula: C22H24BrFN4O2 Solubility: DMSO (30 mg/ml) Ethanol (10 mg/ml) Physical Properties: White or off-white solid Purity: 98% by TLC, NMR (Conforms)