Topotecan HCl
| Overview | |
| Catalog # | bs-83309c-50mg |
| Product Name | Topotecan HCl |
| Specifications | |
| Storage Buffer | Yellow solid |
| Storage Condition | -20°C |
| Target | |
| Product Information | Topotecan HCl is a water-soluble and orally active analog of camptothecin, a DNA topoisomerase I inhibitor.1 Inhibits topoisomerase I in human MCF-7 breast and DU-145 prostate cancer cells, IC50s = 13 and 2 nM respectively.2 Downregulates B-Myb and MycN expression in neuroblastoma cells.3 A clinically useful anticancer agent. |
| Description | CAS Number: 119413-54-6 Chemical Name: DNA topoisomerase I inhibitor Molecular Weight: 457.91 Formula: C23H23N3O5 • HCl Solubility: DMSO (50 mg/ml); water (50 mg/ml) Physical Properties: Yellow solid Purity: >98% by HPLC NMR (Conforms) |
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