Lycorine HCl

Overview
Catalog #	bs-83318c-50mg
Product Name	Lycorine HCl
Specifications
Storage Buffer	White or off-white solid
Storage Condition	RT
Target
Product Information	Arrests cell cycle at G2/M phase and induces apoptosis in tumor cells.1 Inhibits human enterovirus 71 replication by blocking elongation of the viral polyprotein during translation and reduces viral cytopathic effects in mice.2 Dose-dependently extends the circadian period length in mammalian cells by enhancing Bmal1 transcription.3 Selectively inhibits human ovarian cancer cell proliferation and neovascularization (IC50=1.2 µM4. A potent SREBF chaperone (SCAP) degrader (Kd=15.24 nM) which acts via an autophagy-independent lysosomal pathway.5
Description	CAS Number: 2188-68-3 Chemical Name: Protein synthesis inhibitor/SCAP degrader Molecular Weight: 323.77 Formula: C16H17NO4 • HCl Solubility: Water (15 mg/ml) Physical Properties: White or off-white solid Purity: 98% by TLC NMR (Conforms)