Crizotinib
| Overview | |
| Catalog # | bs-83321c-5mg |
| Product Name | Crizotinib |
| Specifications | |
| Storage Buffer | White solid |
| Storage Condition | -20°C |
| Target | |
| Product Information | A potent and selective inhibitor of c-MET and ALK, IC50s=8 and 20 nM respectively.1 Inhibition of cell proliferation was associated with G1-S phase cell cycle arrest and induction of apoptosis in ALK-positive ALCL cells (IC50=30 nM) but not in ALK-negative lymphoma cells.1 Exhibits cytoreductive antitumor efficacy via antiproliferative and antiangiogenic mechanisms.2 Clinically useful anticancer agent.3 |
| Description | CAS Number: 877399-52-5 Chemical Name: c-Met and ALK inhibitor Molecular Weight: 450.34 Formula: C21H22Cl2FN5O Solubility: DMSO (25 mg/ml) Ethanol (25 mg/ml) Physical Properties: White solid Purity: 98% by HPLC, NMR (Conforms) |
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