PP242

Overview
Catalog #	bs-83326c-25mg
Product Name	PP242
Specifications
Storage Buffer	Off-white to beige solid
Storage Condition	-20°C
Target
Product Information	PP242 is an ATP-competitive mTORC1/mTORC2 inhibitor (IC50 = 8 nM) displaying high selectivity over PI 3K family kinases (IC50s =0.102 to 2.2 μM) and modest selectivity over PKC family kinases (IC50s =0.049 to 0.198 μM).1,2 PP 242 (but not rapamycin) induced the death of mouse and human leukemia cells but was much weaker than rapamycin at induction of death of normal lymphocytes.3 Restores lysosomal activity and facilitates clearance of amyloid-β in a mouse model of dry age-related macular degeneration.4 Inhibits glioblastoma cell proliferation, migration, invasiveness, and stemness.5
Description	CAS Number: 1092351-67-1 Chemical Name: Dual mTORC1/mTORC2 inhibitor Molecular Weight: 308.35 Formula: C16H16N6O Solubility: DMSO (8 mg/ml) Physical Properties: Off-white to beige solid Purity: >98% by HPLC NMR (Conforms)