Neratinib

Overview
Catalog #	bs-83362c-100mg
Product Name	Neratinib
Specifications
Storage Buffer	White solid
Storage Condition	-20°C
Target
Product Information	Neratinib is a potent, irreversible inhibitor of HER2/ErbB2 receptor tyrosine kinase and EGFR kinase (IC50’s= 59 nM and 92 nM, respectively). It suppresses receptor autophosphorylation and proliferation, blocks cell-cycle progression and inhibits HER2 signaling in of EGFR-dependent cancer cells and tumor xenograft models.1 Neratinib inhibits proliferation of gefitinib-resistant non-small cell lung cancer cells expressing mutant EGFR.2 Synergizes with dasatinib in HER2-positive cancer cells and xenografts.3 It’s been shown to also inhibit MST1 (IC50 = 37.7 nM).4
Description	CAS Number: 698387-09-6 Chemical Name: Dual EGFR and HER2 inhibitor Molecular Weight: 557.05 Formula: C30H29ClN6O3 Solubility: DMSO (4 mg/ml, warm) Physical Properties: White solid Purity: >98% by HPLC NMR (Conforms)