AZD7648

Overview
Catalog #	bs-83376c-25mg
Product Name	AZD7648
Specifications
Storage Buffer	White solid
Storage Condition	-20°C
Target
Product Information	AZD7648 is a very potent and selective (against 397 kinases) DNA-PK inhibitor (pIC50 = 9.2; cellular pIC50 = 7.0).1 It is a sensitizer of radiation- and doxorubicin-induced DNA damage and sustained tumor regression in xenograft and patient-derived xenograft models.2 AZD7648 significantly enhances precise CRISPR/Cas9 gene editing alone3,4,5 or in combined treatment with a DNA polymerase theta inhibitor (2iHDR cocktail)5.
Description	CAS Number: 2230820-11-6 Chemical Name: DNA-PK inhibitor/CRISPR enhancer Molecular Weight: 380.41 Formula: C18H20N8O2 Solubility: DMSO (5 mg/ml with warming) Physical Properties: White solid Purity: >98% by HPLC NMR (Conforms)