P505-15

Overview
Catalog #	bs-83404c-25mg
Product Name	P505-15
Specifications
Storage Buffer	White solid
Storage Condition	-20°C
Target
Product Information	P505-15 is a highly selective and potent (IC50 = 1-2 nM) inhibitor of spleen tyrosine kinase (Syk).1 It potently inhibited B cell antigen receptor-mediated B cell signaling/activation and basophil degranulation. It displayed anti-inflammatory activity in rodent models of rheumatoid arthritis. P505-15 displayed efficacy in vitro and in vivo in non-Hodgkin lymphoma and chronic lymphocytic leukemia models.2,3 It protected against toxin-induced hepatic fibrosis, associated hepatocellular injury, and hepatocarcinogenesis.4 P505-15 was also found to inhibit PINK1 (IC50 = 0.5-3 µM) in HeLa cells and dopaminergic neurons.5
Description	CAS Number: 1370261-97-4 Chemical Name: Highly selective Syk inhibitor Molecular Weight: 429.91 Formula: C19H23N9O·HCl Solubility: DMSO (25 mg/mL); Water (>25 mg/mL) Physical Properties: White solid Purity: >98% by HPLC NMR (Conforms)