Palbociclib

Overview
Catalog #	bs-83412c-25mg
Product Name	Palbociclib
Specifications
Storage Buffer	Yellow solid
Storage Condition	-20°C
Target
Product Information	Potent and selective inhibitor of Cdk4, IC50 = 11 nM and Cdk6, IC50 = 16 nM.1 Inhibits phosphorylation of Rb protein and cell cycle progression through G1 in primary 5T33MM cells and sensitized these cells to killing by a proteasome inhibitor (bortezomib) in mouse models.2 Induces autophagy and senescence in AGS gastric cancer cells.3 Clinically useful breast cancer agent.4 Cell cycle inhibitors boost tumor immunogenicity.5
Description	CAS Number: 571190-30-2 Chemical Name: CDK4/CDK6 inhibitor Molecular Weight: 447.53 Formula: C24H29N7O2 Solubility: DMSO (2 mg/ml) Physical Properties: Yellow solid Purity: 99% by HPLC/TLC NMR (Conforms)