BMS-309403

Overview
Catalog #	bs-83413c-25mg
Product Name	BMS-309403
Specifications
Storage Buffer	Off-white or pale yellow solid
Storage Condition	-20°C
Target
Product Information	BMS-309403 is a potent (Ki <2 nM FABP4, Ki = 250 nM FABP3, Ki = 350 nM FABP5) and selective inhibitor of the fatty-acid-binding protein aP2 (FABP4).1,2 It demonstrated marked reductions in atherosclerotic lesions in an Apoe-/- mouse model and improved glucose metabolism, reduced inflammation, and increased insulin sensitivity in a Lepob/ob mouse model. BMS-309403 stimulated glucose uptake in myotubes via activation of AMPK.3 It decreased ER stress-associated inflammation in skeletal muscle4 and suppressed inflammation and oxidative stress in mouse and cell models of acute lung injury5.
Description	CAS Number: 300657-03-8 Chemical Name: FABP4 inhibitor Molecular Weight: 474.55 Formula: C31H26N2O3 Solubility: DMSO (>25 mg/ml) Physical Properties: Off-white or pale yellow solid Purity: 98% by HPLC NMR (Conforms)