PLX4720

Overview
Catalog #	bs-83430c-5mg
Product Name	PLX4720
Specifications
Storage Buffer	White solid
Storage Condition	-20°C
Target
Product Information	Potent and selective inhibitor of B-Raf, V600E mutant, IC50=13 nM (Wild type IC50=160 nM).1 It induces cell cycle arrest and apoptosis in B-RafV600E-positive cells and suppresses growth of B-RafV600E-positive xenografts.1 It induces tumor regression and reverses cachexia in a mouse model of human thyroid cancer harboring the B-RafV600E mutation.2 Early stage autophagy inhibitors and ER stress inhibition with 4-phenylbutyric acid increases the sensitivity of resistant cells to PLX4720.3 PLX4720 induces cytoprotective autophagy in thyroid cancer cells via AMPK-ULK1 pathway.4
Description	CAS Number: 918505-84-7 Chemical Name: Mutant B-Raf inhibitor Molecular Weight: 413.82 Formula: C17H14ClF2N3O3S Solubility: DMSO (55 mg/ml with warming) Physical Properties: White solid Purity: >98% by HPLC NMR (Conforms)