PLX4720
| Overview | |
| Catalog # | bs-83430c-5mg |
| Product Name | PLX4720 |
| Specifications | |
| Storage Buffer | White solid |
| Storage Condition | -20°C |
| Target | |
| Product Information | Potent and selective inhibitor of B-Raf, V600E mutant, IC50=13 nM (Wild type IC50=160 nM).1 It induces cell cycle arrest and apoptosis in B-RafV600E-positive cells and suppresses growth of B-RafV600E-positive xenografts.1 It induces tumor regression and reverses cachexia in a mouse model of human thyroid cancer harboring the B-RafV600E mutation.2 Early stage autophagy inhibitors and ER stress inhibition with 4-phenylbutyric acid increases the sensitivity of resistant cells to PLX4720.3 PLX4720 induces cytoprotective autophagy in thyroid cancer cells via AMPK-ULK1 pathway.4 |
| Description | CAS Number: 918505-84-7 Chemical Name: Mutant B-Raf inhibitor Molecular Weight: 413.82 Formula: C17H14ClF2N3O3S Solubility: DMSO (55 mg/ml with warming) Physical Properties: White solid Purity: >98% by HPLC NMR (Conforms) |
Frequently asked questions
Which applications is PLX4720 (bs-83430C) validated for, and at what dilution?
bs-83430C is validated for Life Science( N/A).
How should bs-83430C be stored?
-20°C Storage buffer: White solid