L6H21
| Overview | |
| Catalog # | bs-83443c-25mg |
| Product Name | L6H21 |
| Specifications | |
| Storage Buffer | White solid |
| Storage Condition | -20°C |
| Target | |
| Product Information | L6H21 binds to MD-2 (myeloid differentiation protein-2, Kd=33.3 µM) and blocks its interaction with TLR4 (toll-like receptor 4) in LPS-stimulated cells, inhibiting TNFα and IL-6 production.1 Attenuates disease progression in a high-fat diet (HFD) induced NASH mouse model.2 Inhibits obesity-induced cardiomyopathy and fibrosis.3 Reduces ethanol plus LPS-induced liver injury via inhibition of NLRP3 inflammasome activation.4 Provides cardioprotective effects5 and protects against cognitive impairment and brain pathologies in HFD prediabetic rats6. Cell permeable. Active in vivo. |
| Description | CAS Number: 24533-47-9 Chemical Name: MDL/TLR4 interaction inhibitor Molecular Weight: 298.34 Formula: C18H18O4 Solubility: DMSO (60 mg/ml) Physical Properties: White solid Purity: 98% by HPLC NMR (Conforms) |
Frequently asked questions
Which applications is L6H21 (bs-83443C) validated for, and at what dilution?
bs-83443C is validated for Life Science( N/A).
How should bs-83443C be stored?
-20°C Storage buffer: White solid