L6H21

Overview
Catalog #	bs-83443c-25mg
Product Name	L6H21
Specifications
Storage Buffer	White solid
Storage Condition	-20°C
Target
Product Information	L6H21 binds to MD-2 (myeloid differentiation protein-2, Kd=33.3 µM) and blocks its interaction with TLR4 (toll-like receptor 4) in LPS-stimulated cells, inhibiting TNFα and IL-6 production.1 Attenuates disease progression in a high-fat diet (HFD) induced NASH mouse model.2 Inhibits obesity-induced cardiomyopathy and fibrosis.3 Reduces ethanol plus LPS-induced liver injury via inhibition of NLRP3 inflammasome activation.4 Provides cardioprotective effects5 and protects against cognitive impairment and brain pathologies in HFD prediabetic rats6. Cell permeable. Active in vivo.
Description	CAS Number: 24533-47-9 Chemical Name: MDL/TLR4 interaction inhibitor Molecular Weight: 298.34 Formula: C18H18O4 Solubility: DMSO (60 mg/ml) Physical Properties: White solid Purity: 98% by HPLC NMR (Conforms)