VE-821

Overview
Catalog #	bs-83444c-5mg
Product Name	VE-821
Specifications
Storage Buffer	Beige solid
Storage Condition	-20°C
Target
Product Information	VE-821 is a potent and selective ATP-competitive ATR (Ataxia-telangiectasia and Rad3-related protein) inhibitor, Ki=13 nM.1 Increases the sensitivity of pancreatic2 and ovarian3 cancer cells to radiation and chemotherapy. Increased replication stress induced by PARP inhibitors or chemotherapeutic agents increases sensitivity to VE-821 in neuroblastoma cells.4 Enhances the cytotoxicity of DNA damaging agents.5
Description	CAS Number: 1232410-49-9 Chemical Name: ATR inhibitor Molecular Weight: 368.41 Formula: C18H16N4O3S Solubility: DMSO (40 mg/ml) Physical Properties: Beige solid Purity: 98% by HPLC NMR (Conforms)