10074-G5

Overview
Catalog #	bs-83447c-25mg
Product Name	10074-G5
Specifications
Storage Buffer	Orange solid
Storage Condition	-20°C
Target
Product Information	Inhibits c-Myc by disrupting c-Myc/Max heterodimer formation and inhibiting its transcriptional activity.1 10074-G5 binds to the c-Myc bHLHZip domain with Kd=2.8 mM.1 It was cytotoxic in C-Myc-overexpressing cell lines (IC50s = 13 to 15 mM) but was not active in vivo due to rapid metabolism.2 10074-G5 is a useful tool to probe for involvement of c-Myc involvement in cellular processes.3,4 Binds to and sequesters the intrinsically disordered amyloid-β (Aβ) in its monomeric soluble state and rescues a C. elegans model of Aβ-associated toxicity.5
Description	CAS Number: 413611-93-5 Chemical Name: c-Myc inhibitor Molecular Weight: 332.32 Formula: C18H12N4O3 Solubility: DMSO (40 mg/ml) Physical Properties: Orange solid Purity: 98% by TLC NMR (Conforms)