BG45

Overview
Catalog #	bs-83450c-25mg
Product Name	BG45
Specifications
Storage Buffer	Beige solid
Storage Condition	-20°C
Target
Product Information	Potent and selective HDAC3 inhibitor (IC50 = 289 nM), IC50s for HDAC1, 2 and 6 = 2, 2.2 and >20 mM respectively.1 Inhibits tumor growth in a mouse xenograft model of human multiple myeloma.1 Downregulates expression of DNA methyltransferase 1.2 Increases expression of synaptic proteins in exogenous Aβ-treated cells and mice.3 Rescues synaptic damage and neuron loss in APP-transfected cells (15 mM) and APP/PS1 mice (30 mg/kg).4
Description	CAS Number: 926259-99-6 Chemical Name: HDAC3 selective inhibitor Molecular Weight: 214.23 Formula: C11H10N4O Solubility: DMSO (45 mg/ml) Physical Properties: Beige solid Purity: >98% by HPLC NMR (Conforms)