BMH-21

Overview
Catalog #	bs-83455c-25mg
Product Name	BMH-21
Specifications
Storage Buffer	Orange solid
Storage Condition	-20°C
Target
Product Information	A planar heterocyclic DNA intercalator that inhibits RNA polymerase I (Pol I), IC50 = 0.6 µM in U2OS cells, but not Pols II or III, blocking transcription elongation without inducing the DNA damage response.1-3 Inhibition disengages Pol I from chromatin, resulting in proteasome-dependent destruction of Pol I subunit RPA194.4 At nanomolar concentrations it also activates p53 in A375 cells.5
Description	CAS Number: 896705-16-1 Chemical Name: RNA polymerase I inhibitor Molecular Weight: 360.42 Formula: C21H20N4O2 Solubility: DMSO (13 mg/ml with warming) Physical Properties: Orange solid Purity: >98% by HPLC NMR (Conforms)