TH10785
| Overview | |
| Catalog # | bs-83456c-25mg |
| Product Name | TH10785 |
| Specifications | |
| Storage Buffer | Off-white solid |
| Storage Condition | -20°C |
| Target | |
| Product Information | An 8-oxo guanine DNA glycosylase 1 (OGG1) activator. Oxidative DNA damage is recognized by OGG1 which then excises 8-oxoguanine, leaving a substrate for apurinic endonuclease 1 (APE1) and initiating DNA repair. TH10785 binds to Phe319 and Gly42 of OGG1 increasing it catalytic activity 10-fold and generating a previously undescribed β,δ-lyase enzymatic function. TH10785 increases OGG1 recruitment to and repair of oxidative DNA damage. Increased repair of oxidative DNA damage by small molecules may have therapeutic applications in various diseases and aging.1 |
| Description | CAS Number: 1002801-51-5 Chemical Name: OGG1 activator Molecular Weight: 267.38 Formula: C17H21N3 Solubility: DMSO (50 mg/ml) Physical Properties: Off-white solid Purity: >98% by TLC NMR (Conforms) |
Frequently asked questions
Which applications is TH10785 (bs-83456C) validated for, and at what dilution?
bs-83456C is validated for Life Science( N/A).
How should bs-83456C be stored?
-20°C Storage buffer: Off-white solid