SU9516

Overview
Catalog #	bs-83457c-25mg
Product Name	SU9516
Specifications
Storage Buffer	Orange solid
Storage Condition	-20°C
Target
Product Information	Cyclin-dependent kinase inhibitor, IC50s= 0.02-0.03, 0.04-0.2, 0.2-1.7 and 0.9 µM for cdk2, cdk1, cdk4, cdk9 respectively.1,2 Inhibits phosphorylation of retinoblastoma protein pRb, causing enhanced pRb/E2f complex formation, cell cycle arrest at G1 and G2-M and apoptosis.3 Down-regulates antiapoptotic protein Mcl-1 expression resulting in mitochondrial injury and cell death.4 Inhibits epithelial-mesenchymal transition (IC50=1.21 µM) a crucial pathological event in tumor cell budding and metastasis.5 Cell permeable.
Description	CAS Number: 377090-84-1 Chemical Name: CDK inhibitor (pan-specific) Molecular Weight: 241.25 Formula: C13H11N3O2 Solubility: DMSO (25 mg/ml) Physical Properties: Orange solid Purity: >98% by HPLC NMR (Conforms)