ARV-110

Overview
Catalog #	bs-83711c-5mg
Product Name	ARV-110
Specifications
Storage Buffer	Pale yellow solid
Storage Condition	-20°C
Target
Product Information	ARV-110 is a CRBN-based PROTAC protein degrader that recruits the cereblon-containing E3 ubiquitin ligase to direct the proteasomal degradation of the androgen receptor (AR). It selectively degrades wild-type AR and most clinically relevant mutants with low nM potency.1 ARV-110 is the first PROTAC to enter the clinic.2 Analytical methods suitable for pharmacokinetic studies have been developed.3
Description	CAS Number: 2222112-77-6 Chemical Name: N-[trans-4-(3-Chloro-4-cyanophenoxy)cyclohexyl]-6-[4-[[4-[2-(2,6-dioxo-3-piperidinyl)-6-fluoro-2,3-dihydro-1,3-dioxo-1H-isoindol-5-yl]-1-piperazinyl]methyl]-1-piperidinyl]-3-pyridazinecarboxamide Molecular Weight: 812.3 Formula: C41H43ClFN9O6 Solubility: DMSO (25 mg/ml) Physical Properties: Pale yellow solid Purity: 98% by HPLC NMR (Conforms)