BI-3406

Overview
Catalog #	bs-83739c-5mg
Product Name	BI-3406
Specifications
Storage Buffer	White solid
Storage Condition	-20°C
Target
Product Information	BI-3406 is a potent (IC50 = 5 nM), selective, and orally bioavailable SOS1 inhibitor.1 It blocks SOS1 interaction with KRAS preventing activation of KRAS. BI-3406 was active against multiple cancer cell types and xenograft models harboring various KRAS mutant alleles including G12C,V,S,A,and G13D. It displayed strong synergistic effects with the MEK inhibitor trametinib1,2 and this combination was able to overcome resistance to the KRAS inhibitors sotorasib and adagrasib3. BI-3406 acted synergistically with the KRAS inhibitor adagrasib in KRAS G12C mutant lung and colorectal cancer models.4
Description	CAS Number: 2230836-55-0 Chemical Name: N-[(1R)-1-[3-Amino-5-(trifluoromethyl)phenyl]ethyl]-7-methoxy-2-methyl-6-[(3S)-oxolan-3-yl]oxyquinazolin-4-amine Molecular Weight: 462.47 Formula: C23H25F3N4O3 Solubility: DMSO (>70 mg/ml) Physical Properties: White solid Purity: >98% by HPLC NMR (Conforms)