Fostamatinib disodium

Overview
Catalog #	bs-83756c-5mg
Product Name	Fostamatinib disodium
Specifications
Storage Buffer	White solid
Storage Condition	-20°C
Target
Product Information	Fostamatinib is a prodrug of the spleen tyrosine kinase inhibitor (Syk) R406 and is approved for the treatment of chronic immune thrombocytopenia. It has demonstrated significant reduction in inflammatory mediators such as TNFα, IL-1, IL-6, and IL-8 in arthritis models.1 Syk IC50 = 41 nM – Fostamatinib also inhibits Flt3, Lyn, and Lck with similar potency in vitro but displays higher selectivity Syk in cellular assays.2 Significantly inhibits LPS-induced inflammatory response via blocking STAT1/3 signaling.3 Fostamatinib restored myeloid homeostasis in severe COVID-19.4 Displayed synergistic effects with anti-PDL1 therapy against neuroblastoma.5 Fostamatinib induces metabolic reprogramming of acute myeloid leukemia stem cells.6
Description	CAS Number: 1025687-58-4 Chemical Name: [6-[[5-Fluoro-2-(3,4,5-trimethoxyanilino)pyrimidin-4-yl]amino]-2,2-dimethyl-3-oxopyrido[3,2-b][1,4]oxazin-4-yl]methyl phosphate disodium salt Molecular Weight: 624.43 Formula: C23H24FN6O9P·2Na Solubility: DMSO (12 mg/ml with warming) Physical Properties: White solid Purity: >98% by HPLC NMR (Conforms)