Idasanutlin

Overview
Catalog #	bs-83758c-5mg
Product Name	Idasanutlin
Specifications
Storage Buffer	White solid
Storage Condition	-20°C
Target
Product Information	Idasanutlin is a potent (IC50 = 6 nM) and selective inhibitor of MDM2, the primary negative regulator of p53.1 It blocks the p53-MDM2 interaction activating the p53 pathway leading to cell cycle arrest and apoptosis. Idasanutlin has displayed efficacy in the treatment of multiple cancers alone and in combination with other chemotherapeutics.2-6
Description	CAS Number: 1229705-06-9 Chemical Name: 4-[[(2R,3S,4R,5S)-3-(3-Chloro-2-fluorophenyl)-4-(4-chloro-2-fluorophenyl)-4-cyano-5-(2,2-dimethylpropyl)pyrrolidine-2-carbonyl]amino]-3-methoxybenzoic acid Molecular Weight: 616.49 Formula: C31H29Cl2F2N3O4 Solubility: DMSO (>25 mg/ml) Physical Properties: White solid Purity: >98% by HPLC NMR (Conforms)