(R)-GNE-140
| Overview | |
| Catalog # | bs-83766c-5mg |
| Product Name | (R)-GNE-140 |
| Specifications | |
| Storage Buffer | Off-white to pale orange solid |
| Storage Condition | -20°C |
| Target | |
| Product Information | (R)-GNE-140 is a potent (IC50’s: LDHA = 3 nM, LDHB = 5 nM, LDHC = 5 nM) pan-lactate dehydrogenase inhibitor.1 It significantly decreased lactate levels in vivo, although the effects were transient. GNE-140 suppressed lactic acid production, severely stunted glucose utilization, and impeded the anaerobic glycolytic pathway in MDA-MB-231 triple negative breast cancer cells.2 |
| Description | CAS Number: 2003234-63-5 Chemical Name: (2R)-5-(2-Chlorophenyl)sulfanyl-4-hydroxy-2-(4-morpholin-4-ylphenyl)-2-thiophen-3-yl-1,3-dihydropyridin-6-one Molecular Weight: 499.04 Formula: C25H23ClN3O3S2 Solubility: DMSO (>25 mg/ml) Physical Properties: Off-white to pale orange solid Purity: >98% by HPLC NMR (Conforms) |
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