HPV L2 Polyclonal Antibody

Applications

  • IHC-P
  • IF(IHC-P)

Reactivity

  • Virus
Overview
Catalog # bs-8547R
Product Name HPV L2 Polyclonal Antibody
Applications IHC-P, IF(IHC-P)
Specificity This antibody may detect Minor capsid protein L2 in HPV16, HPV31, HPV35, HPV43, HPV11
Reactivity Virus
Specifications
Conjugation Unconjugated
Host Rabbit
Source KLH conjugated synthetic peptide derived from HPV16 L2
Immunogen Range 1-50/473
Clonality Polyclonal
Isotype IgG
Concentration 1ug/ul
Purification Purified by Protein A.
Storage Aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for 12 months.
Target
Gene ID 1489081
Swiss Prot P03107
Subcellular location Nucleus
Synonyms Minor capsid protein L2; L2
Background Minor protein of the capsid that localizes along the inner surface of the virion, within the central cavities beneath the L1 pentamers. Plays a role in capsid stabilization through interaction with the major capsid protein L1. Once the virion enters the host cell, L2 escorts the genomic DNA into the nucleus by promoting escape from the endosomal compartments and traffic through the host Golgi network. Plays a role through its interaction with host dynein in the intracellular microtubule-dependent transport of viral capsid toward the nucleus. Mediates the viral genome import into the nucleus through binding to host importins. Once within the nucleus, L2 localizes viral genomes to host PML bodies in order to activate early gene expression for establishment of infection. Later on, promotes late gene expression by interacting with the viral E2 protein and by inhibiting its transcriptional activation functions. During virion assembly, encapsidates the genome by direct interaction with the viral DNA.
Application Dilution
IHC-P 1:200-400
IF(IHC-P) 1:50-200